The progress achieved in biology during the last century has led to development of mathematical and computer modelling of functioning regulatory mechanisms (regulatorika) in molecular-genetic processes in living systems. In this work we consider one of the possible methods for mathematical and computer mod- elling of molecular-genetic systems regulatorika. The corresponding equations (in the class of delay functional-differential equations) are developed, using the approaches by B.Goodwin, Bl. Sendov, M. Eigen, B.A. Ratner, and taking into account of tempo- rary relations, presence of multifunctional feedback and cooperative nature of processes in cellfs regulatory loops. Results on the regulatorika for uniform molecular-genetic systems, as well as the problem of the origin and development of hierarchical molecular- genetic systems are considered. Results of using the considered method for analyzing cellfs molecular-genetic systems in the presence of the alien genes (on the example of hepatic cell infections by hepatitis B virus) are given.